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Hello. Here in Texas, whitetails are not the size of the ones in the northeast. I've cleanly killed several whitetails over the years with handguns, but will not shoot unless they're close. The farthest shot I've taken has been 40 yards with perfect conditions. Most have been considerably closer. Last year, I was able to take deer with a .45 Colt S&W Mountain Gun using a 250-gr XTP handload, and with a .45 ACP using a 200-gr XTP as well as one with a 9mm using a 124-gr XTP. All gave complete broadside penetration.
Best.
Best.